2015年10月23日

今年 的PediaBlog 探索了斗地主在线组(这里, 这里这里)由数以万亿计的细菌组成,它们与每个人体细胞共生,并分别影响着我们每个人以及整个社区的健康。莫伊斯·韦拉斯克斯·马诺夫 奇迹 是否一个’自己的(大概是健康的)粪便中充满了肠道细菌,有朝一日可以在需要时用作药物,例如在抗生素疗程用于细菌感染后,癌症化疗期间或在干细胞移植之前(当抗生素和化疗药物的混合物 故意 消除斗地主在线组的斗地主在线成员):

到去年八月,我的一岁儿子已接受了五疗程的抗生素治疗耳部反复感染。令人震惊。到10岁时,平均每个美国孩子已经接受了10道课程,一些斗地主在线学家认为,即使一年一门课程也太多了,以至于它可能损害我们的原生斗地主在线生态系统,并产生深远的影响。

我儿子开局令人担忧。我想知道为什么医生没有更加努力地防止这种附带损害,而不是通过商店购买的益生菌,而是通过“斗地主在线修复”?我们为什么不给患者抗生素后再给他们注入斗地主在线呢?

的scientific term for this is “autologous 粪便移植.” In theory, it could work like a system reboot disk works for your computer. You’d freeze your feces, which are roughly half microbes, and when your 斗地主在线组 became corrupted or was depleted with antimicrobials, you could “reinstall” it from a backup copy.

 

的“fecal transplant” concept isn’新的。 Velasquez-Manoff说,该技术已在60年前成功尝试过,而今天,它已成为治疗艰难梭菌(Clostridium difficile)的有效方法(“C. diff”) colitis. 的idea of “banking stool” —收集,冻结和保存一个’需要一段时间的健康斗地主在线组— is starting to take hold in medical facilities around the country. For children, stool banking and 粪便移植ation may not be as simple a proposition as it is with adults. For instance, Velasquez-Manoff’s son got ear tubes to prevent the need for more 抗生素类 but not a 粪便移植:

I didn’t give my son a self-transplant. 的approach is unproven, and anyway, I hadn’t stored any of his microbes from his pre-antibiotic days. Even if I had, as the Stanford microbiologists Justin and Erica Sonnenburg reminded me, self-transplants aren’t as straightforward for children as they are for adults. 的infant microbiota changes from month to month, moving erratically toward an adultlike state. If I were to store microbes from month six, and reintroduce them at month 12, the microbial community might no longer be appropriate for that stage of development.

但是很明显,这个想法需要测试。这可能是预防感染和一定比例的终身慢性疾病的一种方法,而不是使用花哨的药物或昂贵的程序,而只是通过在抗斗地主在线干扰后恢复我们已经携带的斗地主在线。

 

 

(Yahoo!图片)

 

一种对吞咽苦味药的反应